Coronavirus Vaccine Candidates

Coronaviruses without preventive vaccines are the Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV), and the novel coronavirus SARS-CoV-2, which was initially detected in Wuhan, China by the WHO, during December 2019.

To date, more than 1,000 studies addressing various aspects of COVID-19 are registered on, including more than 600 interventional studies and randomized clinical trials (RCTs). Preliminary results from some RCTs have already been reported in social media and the press.

There are various approaches and different technologies developing vaccine candidates against the SARS-CoV-2 coronavirus. These approaches include, but are not limited to, Viral vector vaccine, DNA vaccine, RNA vaccine, Live-attenuated vaccine, and Protein-based vaccine.

As of May 28, 2020, the US FDA has not approved any preventive or therapeutic coronavirus vaccines for use against the SARS, MERS, or the SARS-CoV-2 coronaviruses.

SARS-CoV-2 Coronavirus Vaccine Candidates Conducting Human Clinical Trials

Coronavirus Clinical Trial Overview

The need to rapidly develop a vaccine against SARS-CoV-2 comes at a time of the explosion in basic scientific understanding, including in areas such as genomics and structural biology, that is supporting a new era in vaccine development, commented an article in NEJM on May 21, 2020.

Among those with the greatest potential for speed are DNA- and RNA-based platforms, followed by those for developing recombinant-subunit vaccines. RNA and DNA vaccines can be made quickly because they require no culture or fermentation, instead of using synthetic processes.

How will interested persons, clinicians, and politicians understand the results of these much-anticipated and critically needed clinical trials? This editorial published in JAMA on May 4, 2020, presents a clear overview.

COVID-19 disease pandemic news is available at

Content sources on this webpage include, but are not limited to, the WHO, the CDC, industry studies, and The content was Fact-Checked by Dr. Robert Carlson and other healthcare professionals.