A limited, non-peer-reviewed study based on data provided by UK Biobank released on November 9, 2020, found (8) genetic variants significantly increase the risk of COVID-19 mortality among (45) patients with British ancestry.
The identified risk factors on Chromosomes 38 2, 6, 7, 8, 10, 16, and 17 contain genetic variants and genes related to cilia dysfunctions 39 (DNAH7 and CLUAP1), cardiovascular diseases, thromboembolic disease, mitochondrial dysfunctions, and innate immune system. DNAH7 has been reported recently as the most down-regulated gene after infecting human bronchial epithelial cells with the SARS-CoV2 coronavirus.
These researchers stated 'This new finding may provide evidence and clues for better understanding the molecular pathogenesis of COVID-19 and the genetic basis of heterogeneous susceptibility, with potential impact on therapeutic options for patients.'
The research was supported in part by the US National Institutes of Health.