COVID-19 Immune Imprinting 2023
COVID-19 Immune Imprinting April 2023
The impact of innate and adaptive immunities related to COVID-19 vaccination's original antigenic effect will continue to be explored in April 2023. Original antigenic sin is an attribute of immune memory that leads to greater induction of antibodies specific to the first-encountered variant of an immunogen compared with subsequent variants. To offer potent protection against future SARS-CoV-2 coronavirus variants, second-generation COVID-19 vaccines may need to redirect immunity to epitopes associated with immune escape and not merely boost immunity toward conserved domains in preimmune individuals.
The World Health Organization Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC) stated on April 14, 2023, that in vitro evidence shows that immune imprinting occurs with repeated exposure to the same antigen from COVID-19 vaccines.
COVID-19 Vaccine Immunological Imprinting
April 25, 2023 - Dr. Katelyn Jetelina, MPH Ph.D., wrote, 'We know imprinting is a thing with COVID-19. And we should expect imprinting. However, the most significant influence of imprinting occurs after the first exposure to the SARS-CoV-2 coronavirus through vaccination or infection. We still don't have good evidence that imprinting is harming protection.
April 19, 2023 - In the peer-review journal Immunity, researchers explained immunological imprinting, its underlying principles, and its potential role with COVID-19 vaccines.
April 14, 2023 - The WHO announced that in vitro evidence shows that immune imprinting occurs with repeated exposure to the same antigen from COVID-19 vaccines.
April 25, 2022 - Study: Immunopathological changes, complications, sequelae, and immunological memory in COVID-19 patients.
April 6, 2022 - Dr. Katelyn Jetelina, MPH Ph.D., published an article: Original antigenic sin: Are boosters a threat? Are there other risks to getting another booster, like "original antigenic sin?"
February 7, 2022 - The journal Science wrote: A person's first exposure to a type of virus can noticeably affect their later responses to similar ones.